Beyond-Use Date (BUD) for Compounded Tirzepatide and Semaglutide
The Beyond-Use Date (BUD) for compounded Tirzepatide and Semaglutide is as follows:
Unopened Vial:
The BUD is typically 120 days from the compounding date, provided the vial is stored in a refrigerated environment as per pharmacy guidelines.
Opened/Punctured Vial:
Once opened, the BUD is often specified as 28 days; however, some pharmacies may extend the BUD up to 120 days under ideal storage and refrigeration conditions. It’s recommended to consult your pharmacy for specific guidelines. For 3-month supplies, store the medication correctly and follow the pharmacy’s storage and stability guidelines to maintain its potency.
Shipping Guidelines
Tirzepatide is shipped using insulated packaging with cold packs to maintain the medication’s stability during transit. This is crucial for temperature-sensitive medications to prevent exposure to heat and other environmental factors. While refrigeration during shipping is not mandatory, refrigerating the medication promptly upon receipt is essential to preserve its effectiveness. Avoid exposing the vial to direct sunlight during shipping.
Storage Recommendations
Refrigeration: Store tirzepatide in a refrigerator. It remains stable at room temperature (up to 86°F/30°C) for a maximum of 56 days.
Higher Temperatures: Tirzepatide can retain its potency after brief exposure to higher temperatures (up to 104°F/40°C) for a period of up to 3 days. Following such exposure, return the medication to refrigeration immediately.
Avoid Direct Sunlight: Extended exposure to strong light sources, like direct sunlight, should be avoided as it may degrade the medication. Brief light exposure, such as from opening a refrigerator, does not impact its stability.
FAQs
I left my tirzepatide out overnight. Is it still safe to use?
Yes, tirzepatide is stable at room temperature for up to 56 days. Leaving it out overnight does not impact potency. However, prolonged exposure to temperatures above 86°F/30°C should be avoided. If this occurs, return the medication to refrigeration promptly and ensure proper storage moving forward.
If the tirzepatide vial was briefly exposed to light, is it still effective?
Yes, brief exposure to light (e.g., when opening a refrigerator) does not reduce the medication’s efficacy. Avoid prolonged exposure to direct sunlight. Always store the vial in a shaded, refrigerated area to maintain stability.